Article
Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices.
Kidney international - 1 Dec 2010
Chen Shoujun, Wassenhove-McCarthy Deborah, Yamaguchi Yu, Holzman Lawrence, van Kuppevelt Toin H, Orr A Wayne, Funk Steven, Woods Ann, McCarthy Kevin
Abstract excerpt
Podocytes adhere to the glomerular basement membrane by cell surface receptors. Since in other cells these adhesions are enhanced by cell surface proteoglycans, we examined the contribution of these molecules and their glycosaminoglycan side chains to podocyte adhesion by developing immortalized podocyte cell lines with (control) or without (mutant) heparan sulfate glycosaminoglycan chains. In adhesion assays...
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