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Article

Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria.

Kidney international - 1 Aug 2008

Chen Shoujun, Wassenhove-McCarthy Deborah J, Yamaguchi Yu, Holzman Lawrence B, van Kuppevelt Toin H, Jenniskens Guido J, Wijnhoven Tessa J, Woods Ann C, McCarthy Kevin J

Abstract excerpt

Podocytes synthesize the majority of the glomerular basement membrane components with some contribution from the glomerular capillary endothelial cells. The anionic charge of heparan sulfate proteoglycans is conferred by covalently attached heparan sulfate glycosaminoglycans and these are thought...

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Identifiers

PMID: 18480751
DOI: 10.1038/ki.2008.159
PMCID: PMC8092444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18480751-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria.PMID 18480751Read ↗

Podocyte-specific deletion of NDST1, a key enzyme in the sulfation of heparan sulfate glycosaminoglycans, leads to abnormalities in podocyte organization in vivo.Semantic proximity Read ↗

Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria.Semantic proximity Read ↗

Models for studies of proteoglycans in kidney pathophysiology.Semantic proximity Read ↗

Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier.Semantic proximity Read ↗

Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality.Semantic proximity Read ↗

Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity.Semantic proximity Read ↗

Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane.Semantic proximity Read ↗

Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains.Semantic proximity Read ↗

Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices.Semantic proximity Read ↗

Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice.Semantic proximity Read ↗

The molecular phenotype of heparan sulfate in the Hs2st-/- mutant mouse.Semantic proximity Read ↗

Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1.Semantic proximity Read ↗

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