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Article

Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2004

Zcharia Eyal, Metzger Shula, Chajek-Shaul Tova, Aingorn Helena, Elkin Michael, Friedmann Yael, Weinstein Talia, Li Jin-Ping, Lindahl Ulf, Vlodavsky Israel

Abstract excerpt

We have generated homozygous transgenic mice (hpa-tg) overexpressing human heparanase (endo-beta-D-glucuronidase) in all tissues and characterized the involvement of the enzyme in tissue morphogenesis, vascularization, and energy metabolism. Biochemical analysis of heparan sulfate (HS) isolated from newborn mice and adult tissues revealed a profound decrease in the size of HS chains derived from hpa-tg vs....

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PMID: 14769819
DOI: 10.1096/fj.03-0572com

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