Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity.

doi:10.2353/ajpath.2007.061116

Article

Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity.

The American journal of pathology - 1 Jul 2007

Harvey Scott J, Jarad George, Cunningham Jeanette, Rops Angelique L, van der Vlag Johan, Berden Jo H, Moeller Marcus J, Holzman Lawrence B, Burgess Robert W, Miner Jeffrey H

Abstract excerpt

Glomerular charge selectivity has been attributed to anionic heparan sulfate proteoglycans (HSPGs) in the glomerular basement membrane (GBM). Agrin is the predominant GBM-HSPG, but evidence that it contributes to the charge barrier is lacking, because newborn agrin-deficient mice die from neuromuscular defects. To study agrin in adult kidney, a new conditional allele was used to generate podocyte-specific...

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