Article
Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance.
The Journal of biological chemistry - 1 Jan 2010
Stanford Kristin I, Wang Lianchun, Castagnola Jan, Song Danyin, Bishop Joseph R, Brown Jillian R, Lawrence Roger, Bai Xaiomei, Habuchi Hiroko, Tanaka Masakazu, Cardoso Wellington V, Kimata Koji, Esko Jeffrey D
Abstract excerpt
Hepatic clearance of triglyceride-rich lipoproteins depends on heparan sulfate and low density lipoprotein receptors expressed on the basal membrane of hepatocytes. Binding and uptake of the lipoproteins by way of heparan sulfate depends on the degree of sulfation of the chains based on accumulation of plasma triglycerides and delayed clearance of triglyceride-rich lipoproteins in mice bearing a...
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