Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2013

Heller Kristin N, Montgomery Chrystal L, Janssen Paul Ml, Clark K Reed, Mendell Jerry R, Rodino-Klapac Louise R

Abstract excerpt

Duchenne muscular dystrophy (DMD) is a severe muscle disease caused by mutations in the DMD gene, with loss of its gene product, dystrophin. Dystrophin helps link integral membrane proteins to the actin cytoskeleton and stabilizes the sarcolemma during muscle activity. We investigated an alternat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dependovirus
Share to Dystrophin
Share to Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Integrin alpha Chains

Share to Mice, Inbred mdx

Share to Muscular Dystrophy, Duchenne

Share to Sarcolemma

Source

Open in PubMed Open full text

Identifiers

PMID: 23319059
DOI: 10.1038/mt.2012.281
PMCID: PMC3589167

Genes

ITGA7
DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23319059-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice.PMID 23319059Read ↗

Laminin-111 protein therapy prevents muscle disease in the <i>mdx</i> mouse model for Duchenne muscular dystrophySemantic proximity Read ↗

Enhanced Expression of the α7β1 Integrin Reduces Muscular Dystrophy and Restores Viability in Dystrophic MiceSemantic proximity Read ↗

Severe muscular dystrophy in mice that lack dystrophin and α7 integrinSemantic proximity Read ↗

AAV-mediated gene transfer restores a normal muscle transcriptome in a canine model of X-linked myotubular myopathySemantic proximity Read ↗

Systemic AAV Micro-dystrophin Gene Therapy for Duchenne Muscular DystrophySemantic proximity Read ↗

An engineered AAV targeting integrin alpha V beta 6 presents improved myotropism across speciesSemantic proximity Read ↗

Increasing α<sub>7</sub>β<sub>1</sub>-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expressionSemantic proximity Read ↗

Laminin-111 protein therapy enhances muscle regeneration and repair in the GRMD dog model of Duchenne muscular dystrophySemantic proximity Read ↗

Transduction Efficiency of Adeno-Associated Virus Serotypes After Local Injection in Mouse and Human Skeletal MuscleSemantic proximity Read ↗

Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin.Semantic proximity Read ↗

Altered expression of the alpha7beta1 integrin in human and murine muscular dystrophies.Semantic proximity Read ↗

Absence of α7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.