Article
Identification and Characterization of the Cell Type-specific and Developmentally Regulated α7 Integrin Gene Promoter
1 Sept 1996
Abstract excerpt
Expression of alpha7 is mainly confined to skeletal and cardiac muscle in which it appears to be the major laminin-binding integrin. When myoblasts differentiate to myotubes, alpha7 mRNA and protein expression is up-regulated. To explore the mechanisms involved in the tissue-specific and developmentally regulated expression of alpha7, we isolated and characterized a genomic clone containing approximately 2.8...