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Article

Nuclear Expression of Hypoxia-inducible Factor-1α in Clear Cell Renal Cell Carcinoma is Involved in Tumor Progression

19 Nov 2007

Abstract excerpt

OBJECTIVES: The most frequent genomic abnormality in clear cell renal cell carcinoma (cc-RCC) is inactivation of Von Hippel-Lindau gene (VHL). pVHL19 is a ligase promoting proteosomal degradation of hypoxia-inducible factor-1alpha (HIF-1alpha); pVHL30 is associated with microtubules. VHL exert its oncogenetic action both directly and through HIF-1alpha activation. TNM classification is unable to define a correct...

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PMID: 18043042
DOI: 10.1097/pas.0b013e318094fed8

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