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Article

Relevance of nuclear and cytoplasmic von hippel lindau protein expression for renal carcinoma progression.

The American journal of pathology - 1 Sept 2003

Schraml Peter, Hergovich Alexander, Hatz Florian, Amin Mahul B, Lim So D, Krek Wilhelm, Mihatsch Michael J, Moch Holger, Hergovitz Alexander

Abstract excerpt

Alterations of the von Hippel-Lindau tumor-suppressor gene (VHL) on 3p25-p26 are frequent in clear-cell renal-cell carcinoma (RCC). The VHL protein (pVHL) is implicated in cell-cycle control and gene regulation, and requires transcription-dependent nuclear-cytoplasmic trafficking for its function. There are two biologically active VHL protein isoforms: pVHL(30) and pVHL(19). To study prevalence, subcellular...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12937142
DOI: 10.1016/s0002-9440(10)63461-x
PMCID: PMC1868278

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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