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Article

Straightening and sequential buckling of the pore-lining helices define the gating cycle of MscS.

Nature structural & molecular biology - 1 Dec 2007

Akitake Bradley, Anishkin Andriy, Liu Naili, Sukharev Sergei

Abstract excerpt

We describe a mechanism connecting the adaptive behavior of the bacterial mechanosensitive channel MscS to the flexibility of the pore-lining helix TM3. Simulated expansion of the channel structure revealed straightening of a characteristic kink near Gly113 in the open state; return to the closed state produced an alternative kink at Gly121. Patch-clamp experiments showed that higher helical propensity introduced...

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PMID: 18037888
DOI: 10.1038/nsmb1341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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