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Article

The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution.

Science (New York, N.Y.) - 29 Aug 2008

Wang Wenjian, Black Susan S, Edwards Michelle D, Miller Samantha, Morrison Emma L, Bartlett Wendy, Dong Changjiang, Naismith James H, Booth Ian R

Abstract excerpt

How ion channels are gated to regulate ion flux in and out of cells is the subject of intense interest. The Escherichia coli mechanosensitive channel, MscS, opens to allow rapid ion efflux, relieving the turgor pressure that would otherwise destroy the cell. We present a 3.45 angstrom-resolution structure for the MscS channel in an open conformation. This structure has a pore diameter of approximately 13...

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Identifiers

PMID: 18755969
DOI: 10.1126/science.1159262
PMCID: PMC3299565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution.PMID 18755969Read ↗

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