Article
The pathway and spatial scale for MscS inactivation.
The Journal of general physiology - 1 Jul 2011
Kamaraju Kishore, Belyy Vladislav, Rowe Ian, Anishkin Andriy, Sukharev Sergei
Abstract excerpt
The mechanosensitive channel of small conductance (MscS) is a bacterial tension-driven osmolyte release valve with homologues in many walled eukaryotic organisms. When stimulated by steps of tension in excised patches, Escherichia coli MscS exhibits transient opening followed by reversible adaptation and then complete inactivation. Here, we study properties of the inactivation transition, which renders MscS...
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