Autosomal dominant restless legs syndrome maps on chromosome 14q.

doi:10.1093/brain/awg137

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Article

Autosomal dominant restless legs syndrome maps on chromosome 14q.

Brain : a journal of neurology - 1 Jun 2003

Bonati Maria Teresa, Ferini-Strambi Luigi, Aridon Paolo, Oldani Alessandro, Zucconi Marco, Casari Giorgio

Abstract excerpt

Restless legs syndrome (RLS) is a common neurological disorder characterized by an irresistible desire to move the extremities associated with paraesthesia/dysaesthesia. These symptoms occur predominantly at rest and worsen at night, resulting in nocturnal insomnia and chronic sleep deprivation. In this paper, we show significant evidence of linkage to a new locus for RLS on chromosome 14q13-21 region in a...

Topics

Adolescent
Adult
Age of Onset
Aged
Chromosomes, Human, Pair 14
Disease Progression
Female
Genes, Dominant
Genetic Linkage
Genetic Predisposition to Disease
Genotype
Humans
Lod Score
Male
Middle Aged
Nocturnal Myoclonus Syndrome
Pedigree
Polysomnography

Source

Open in PubMed

Identifiers

PMID: 12764067
DOI: 10.1093/brain/awg137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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