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Article

Variation in Niemann-Pick C1-like 1 gene as a determinant of apolipoprotein B-100 kinetics and response to statin therapy in centrally obese men.

Clinical endocrinology - 1 Jul 2008

Chan Dick C, Watts Gerald F, Wang Jian, Hegele Robert A, van Bockxmeer Frank M, Barrett P Hugh R

Abstract excerpt

OBJECTIVE: Niemann-Pick C1-like 1 protein (NPC1L1) plays a key role in lipoprotein metabolism. We examined the association of common genetic polymorphisms in NPC1L1 on apolipoprotein (apo) B-100 metabolism and the response to statin treatment in 37 men with central obesity. RESEARCH METHODS AND PROCEDURE: Very-low density lipoprotein (VLDL) and low-density lipoprotein (LDL)-apoB kinetics were determined using...

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PMID: 18031309
DOI: 10.1111/j.1365-2265.2007.03144.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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