Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The c.-133A > G polymorphism in NPC1L1 gene influences the efficacy of ezetimibe monotherapy on apolipoprotein A1 in hyperlipidemic patients.

Die Pharmazie - 1 Jun 2014

Zsíros N, Bodor M, Varga V, Berta E, Balogh I, Seres I, Paragh G, Harangi M

Abstract excerpt

Niemann-Pick C1-like 1 protein (NPC1L1) plays a critical role in intestinal cholesterol absorption. Previous studies found that the NPC1L1 c.-133A > G SNP, but not other NPC1L1 SNPs, was associated with response to statin treatment and statin-ezetimibe combinations. To date effect of NPC1L1 c.-133A > G SNP on ezetimibe monotherapy has not been studied. Our objective was to examine whether SNP c.-133A > G at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticholesteremic Agents
Share to Apolipoprotein A-I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins B

Share to Azetidines

Share to Creatine Kinase

Share to Ezetimibe

Share to Hyperlipidemias

Share to Spectrophotometry, Ultraviolet

Source

Identifiers

PMID: 24974575

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The c.-133A > G polymorphism in NPC1L1 gene influences the efficacy of ezetimibe monotherapy on apolipoprotein A1 in hyperlipidemic patients.PMID 24974575Read ↗

Gene polymorphism and frequencies of the NPC1L1 gene (rs2072183, rs217434 and rs217428) in Japanese patients with dyslipidemia.Semantic proximity Read ↗

A SNP of NPC1L1 affects cholesterol absorption in Japanese.Semantic proximity Read ↗

Efficacy of ezetimibe is not related to NPC1L1 gene polymorphisms in a pilot study of Chilean hypercholesterolemic subjects.Semantic proximity Read ↗

Sequence variation in NPC1L1 and association with improved LDL-cholesterol lowering in response to ezetimibe treatment.Semantic proximity Read ↗

Analysis of Niemann-Pick C1-like 1 (NPC1L1) genetic polymorphisms and haplotypes in Chinese Han population.Semantic proximity Read ↗

Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly.Semantic proximity Read ↗

Genetic variation in the cholesterol transporter NPC1L1, ischaemic vascular disease, and gallstone disease.Semantic proximity Read ↗

In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers.Semantic proximity Read ↗

The g.-762T>C polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levels.Semantic proximity Read ↗

NPC1L1 rs217434 A > G as a Novel Single Nucleotide Polymorphism Related to Dyslipidemia in a Korean Population.Semantic proximity Read ↗

Effect of ezetimibe coadministered with statins in genotype-confirmed heterozygous FH patients.Semantic proximity Read ↗

Association of rs2072183 SNP and serum lipid levels in the Mulao and Han populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.