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Article

PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge.

Diabetologia - 1 Mar 2007

Franks P W, Ekelund U, Brage S, Luan J, Schafer A J, O'Rahilly S, Barroso I, Wareham N J

Abstract excerpt

AIMS/HYPOTHESIS: The peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein, encoded by the PPARGC1A gene, transcriptionally activates a complex pathway of lipid and glucose metabolism and is expressed primarily in tissues of high metabolic activity such as liver, heart and exercising oxidative skeletal muscle fibre. Ppargc1a-null mice develop systemic dyslipidaemia and hepatic steatosis. In...

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Identifiers

PMID: 17216277
DOI: 10.1007/s00125-006-0580-1
PMCID: PMC2682771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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