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Article

A SNP of NPC1L1 affects cholesterol absorption in Japanese.

Journal of atherosclerosis and thrombosis - 30 Apr 2010

Maeda Tomomi, Honda Akira, Ishikawa Toshio, Kinoshita Makoto, Mashimo Yamato, Takeoka Yoko, Yasuda Daijiro, Kusano Jun, Tsukamoto Kazuhisa, Matsuzaki Yasushi, Teramoto Tamio

Abstract excerpt

AIM: Ezetimibe is known to target Niemann-Pick Type C1 Like1 (NPC1L1), a key protein in intestinal cholesterol absorption, and thus to decrease serum LDL-cholesterol (LDL-C) levels. The response of serum LDL-C levels to ezetimibe was reported to differe among NPC1L1 haplotypes.We analyzed NPC1L1 genotypes in Japanese and investigated differences in markers of cholesterol synthesis/absorption among the genotypes....

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Identifiers

PMID: 20379057
DOI: 10.5551/jat.2451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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