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Article

Niemann-Pick C1 modulates hepatic triglyceride metabolism and its genetic variation contributes to serum triglyceride levels.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2010

Uronen Riikka-Liisa, Lundmark Per, Orho-Melander Marju, Jauhiainen Matti, Larsson Kristina, Siegbahn Agneta, Wallentin Lars, Zethelius Björn, Melander Olle, Syvänen Ann-Christine, Ikonen Elina

Abstract excerpt

OBJECTIVE: To study how Niemann-Pick disease type C1 (NPC1) influences hepatic triacylglycerol (TG) metabolism and to determine whether this is reflected in circulating lipid levels. METHODS AND RESULTS: In Npc1(-/-) mice, the hepatic cholesterol content is increased but the TG content is decreas...

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Source

Identifiers

PMID: 20489167
DOI: 10.1161/ATVBAHA.110.207191

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20489167-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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