Article
P53 gene mutations in pituitary carcinomas.
Endocrine pathology - 1 Jan 2007
Tanizaki Yoshinori, Jin Long, Scheithauer Bernd W, Kovacs Kalman, Roncaroli Federico, Lloyd Ricard V
Abstract excerpt
Although p53 overexpression detected by immunohistochemistry has been reported in pituitary adenomas and carcinomas, genetic mutations in the p53 gene have not been previously detected in these tumors. We analyzed a series of eight pituitary adenomas and six pituitary carcinomas by immunohistochemistry, polymerase chain reaction amplification, and sequencing of p53 exon 5 through exon 8 for genetic mutations....
Topics
- Adenoma
- Adult
- Aged
- Base Sequence
- Carcinoma
- DNA Mutational Analysis
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mutation
- Pituitary Neoplasms
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Suppressor Protein p53