Article
Expression of p53 protein in pituitary adenomas.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 May 2002
Oliveira M C, Marroni C P, Pizarro C B, Pereira-Lima J F, Barbosa-Coutinho L M, Ferreira N P
Abstract excerpt
Inactivating mutations of TP53, a tumor suppressor gene, are associated with abnormal cell proliferation. Although p53 expression is common in many human malignancies, p53 protein has seldom been evaluated in pituitary tumors. When detected, the percentage of p53-positive cells is low, and, in general, it is exclusive for invasive lesions. The aim of the present study was to use immunohistochemistry to determine...
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