Article
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.
The Journal of clinical investigation - 1 Jan 1993
Fagin J A, Matsuo K, Karmakar A, Chen D L, Tang S H, Koeffler H P
Abstract excerpt
The development and progression of thyroid tumors is signaled by phenotype-specific mutations of genes involved in growth control. Molecular events associated with undifferentiated thyroid cancer are not known. We examined normal, benign, and malignant thyroid tissue for structural abnormalities...
Topics
- Adenocarcinoma
- Adenoma
- Amino Acid Sequence
- Base Sequence
- Carcinoma
- Carcinoma, Papillary
- Codon
- Exons
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Thyroid Gland
- Thyroid Neoplasms
- Tumor Cells, Cultured