Article
High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.
The Journal of clinical investigation - 1 Jan 1993
Fagin J A, Matsuo K, Karmakar A, Chen D L, Tang S H, Koeffler H P
Abstract excerpt
The development and progression of thyroid tumors is signaled by phenotype-specific mutations of genes involved in growth control. Molecular events associated with undifferentiated thyroid cancer are not known. We examined normal, benign, and malignant thyroid tissue for structural abnormalities of the p53 tumor suppressor gene. Mutations were detected by single-strand conformation polymorphisms of PCR-amplified...
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