Article
Isolation and functional assessment of common, polymorphic variants of the B-MYB proto-oncogene associated with a reduced cancer risk.
Oncogene - 1 May 2008
Schwab R, Bussolari R, Corvetta D, Chayka O, Santilli G, Kwok J M-M, Ferrari-Amorotti G, Amorotti G F, Tonini G P, Iacoviello L, Bertorelle R, Menin C, Hubank M, Calabretta B, Sala A
Abstract excerpt
The B-MYB proto-oncogene is a transcription factor belonging to the MYB family that is frequently overexpressed or amplified in different types of human malignancies. While it is suspected that B-MYB plays a role in human cancer, there is still no direct evidence of its causative role. Looking for mutations of the B-MYB gene in human cell lines and primary cancer samples, we frequently isolated two nonsynonymous...
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