Article
A c-Myb mutant causes deregulated differentiation due to impaired histone binding and abrogated pioneer factor function.
Nucleic acids research - 27 Jul 2017
Fuglerud Bettina M, Lemma Roza B, Wanichawan Pimthanya, Sundaram Arvind Y M, Eskeland Ragnhild, Gabrielsen Odd S
Abstract excerpt
The transcription factor c-Myb is involved in early differentiation and proliferation of haematopoietic cells, where it operates as a regulator of self-renewal and multi-lineage differentiation. Deregulated c-Myb plays critical roles in leukaemias and other human cancers. Due to its role as a master regulator, we hypothesized it might function as a pioneer transcription factor. Our approach to test this was to...
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