Article
In vitro and in vivo analysis of B-Myb in basal-like breast cancer.
Oncogene - 5 Feb 2009
Thorner A R, Hoadley K A, Parker J S, Winkel S, Millikan R C, Perou C M
Abstract excerpt
A defining feature of basal-like breast cancer, a breast cancer subtype with poor clinical prognosis, is the high expression of 'proliferation signature' genes. We identified B-Myb, a MYB family transcription factor that is often amplified and overexpressed in many tumor types, as being highly expressed in the proliferation signature. However, the roles of B-Myb in disease progression, and its mammary-specific...
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