Article
Functional consequence of the MET-T1010I polymorphism in breast cancer.
Oncotarget - 20 Feb 2015
Liu Shuying, Meric-Bernstam Funda, Parinyanitikul Napa, Wang Bailiang, Eterovic Agda K, Zheng Xiaofeng, Gagea Mihai, Chavez-MacGregor Mariana, Ueno Naoto T, Lei Xiudong, Zhou Wanding, Nair Lakshmy, Tripathy Debu, Brown Powel H, Hortobagyi Gabriel N, Chen Ken, Mendelsohn John, Mills Gordon B, Gonzalez-Angulo Ana M
Abstract excerpt
Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor receptor MET is potentially functionally altered due to an uncommon germline single nucleotide polymorphism (SNP), MET-T1010I, in many cancer lineages including breast cancer where the MET-T1010I SNP is present in 2% of...
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