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Article

Alternative RNA Splicing Produces Multiple Forms of c-Myb with Unique Transcriptional Activities

15 Jan 2008

Abstract excerpt

The c-Myb transcription factor regulates the proliferation and differentiation of hematopoietic cells, and activated alleles of c-myb induce leukemias and lymphomas in animals. Relatively minor changes in the structure of c-Myb protein change the genes that it regulates and can unleash its latent transforming activities. Here, quantitative assays were used to analyze the alternative splicing of human c-myb...

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PMID: 18195038
DOI: 10.1128/mcb.01870-07

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