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Article

Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru.

Antimicrobial agents and chemotherapy - 1 Feb 2008

Zhou Zhiyong, Griffing Sean M, de Oliveira Alexandre Macedo, McCollum Andrea M, Quezada Wilmer Marquino, Arrospide Nancy, Escalante Ananias A, Udhayakumar Venkatachalam

Abstract excerpt

The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum malaria. Microsatellite analysis showed that the dhfr and dhps alleles are of common origin.

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Identifiers

PMID: 18025120
DOI: 10.1128/AAC.00975-07
PMCID: PMC2224716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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