Article
Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western Kenya.
Malaria journal - 4 Jul 2012
Iriemenam Nnaemeka C, Shah Monica, Gatei Wangeci, van Eijk Anna M, Ayisi John, Kariuki Simon, Vanden Eng Jodi, Owino Simon O, Lal Ashima A, Omosun Yusuf O, Otieno Kephas, Desai Meghna, ter Kuile Feiko O, Nahlen Bernard, Moore Julie, Hamel Mary J, Ouma Peter, Slutsker Laurence, Shi Ya Ping
Abstract excerpt
BACKGROUND: Resistance to sulphadoxine-pyrimethamine (SP) in Plasmodium falciparum parasites is associated with mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes and has spread worldwide. SP remains the recommended drug for intermittent preventive treatment for malaria in pregnancy (IPTp) and information on population prevalence of the SP resistance molecular markers in...
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