Article
Surveillance of molecular markers of Plasmodium falciparum resistance to sulphadoxine-pyrimethamine 5 years after the change of malaria treatment policy in Ghana.
The American journal of tropical medicine and hygiene - 1 Dec 2012
Duah Nancy O, Quashie Neils B, Abuaku Benjamin K, Sebeny Peter J, Kronmann Karl C, Koram Kwadwo A
Abstract excerpt
In 2005, sulphadoxine-pyrimethamine (SP) became the drug of choice for intermittent preventive treatment of Plasmodium falciparum malaria in pregnancy (IPTp) in Ghana. Reports suggest the use of SP by others to treat uncomplicated malaria. Because of the increased use of SP, the prevalence of mutations in the genes, dihydrofolate reductase (dhfr), and dihydropteroate synthetase (dhps), linked to SP resistance in...
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