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Article

Historical shifts in Brazilian P. falciparum population structure and drug resistance alleles.

PloS one - 1 Jan 2013

Griffing Sean M, Viana Giselle M Rachid, Mixson-Hayden Tonya, Sridaran Sankar, Alam Mohammad Tauqeer, de Oliveira Alexandre Macedo, Barnwell John W, Escalante Ananias A, Povoa Marinete Marins, Udhayakumar Venkatachalam

Abstract excerpt

Previous work suggests that Brazilian Plasmodium falciparum has limited genetic diversity and a history of bottlenecks, multiple reintroductions due to human migration, and clonal expansions. We hypothesized that Brazilian P. falciparum would exhibit clonal structure. We examined isolates collected across two decades from Amapá, Rondônia, and Pará state (n = 190). By examining more microsatellites markers on more...

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PMID: 23554964
DOI: 10.1371/journal.pone.0058984
PMCID: PMC3598954

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