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Article

Dynamics of malaria drug resistance patterns in the Amazon basin region following changes in Peruvian national treatment policy for uncomplicated malaria.

Antimicrobial agents and chemotherapy - 1 May 2009

Bacon David J, McCollum Andrea M, Griffing Sean M, Salas Carola, Soberon Valeria, Santolalla Meddly, Haley Ryan, Tsukayama Pablo, Lucas Carmen, Escalante Ananias A, Udhayakumar Venkatachalam

Abstract excerpt

Monitoring changes in the frequencies of drug-resistant and -sensitive genotypes can facilitate in vivo clinical trials to assess the efficacy of drugs before complete failure occurs. Peru changed its national treatment policy for uncomplicated malaria to artesunate (ART)-plus-mefloquine (MQ) combination therapy in the Amazon basin in 2001. We genotyped isolates collected in 1999 and isolates collected in 2006 to...

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Identifiers

PMID: 19258269
DOI: 10.1128/AAC.01677-08
PMCID: PMC2681566

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