Article
Geographical spread and structural basis of sulfadoxine-pyrimethamine drug-resistant malaria parasites.
International journal for parasitology - 1 Jun 2021
Chaturvedi Rini, Chhibber-Goel Jyoti, Verma Ishika, Gopinathan Sreehari, Parvez Suhel, Sharma Amit
Abstract excerpt
The global spread of sulfadoxine (Sdx, S) and pyrimethamine (Pyr, P) resistance is attributed to increasing number of mutations in DHPS and DHFR enzymes encoded by malaria parasites. The association between drug resistance mutations and SP efficacy is complex. Here we provide an overview of the geographical spread of SP resistance mutations in Plasmodium falciparum (Pf) and Plasmodium vivax (Pv) encoded dhps and...
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