Article
Importance of polyadenylation in the selective elimination of meiotic mRNAs in growing S. pombe cells.
The EMBO journal - 7 Jul 2010
Yamanaka Soichiro, Yamashita Akira, Harigaya Yuriko, Iwata Ryo, Yamamoto Masayuki
Abstract excerpt
A number of meiosis-specific mRNAs are initially weakly transcribed, but then selectively removed during fission yeast mitotic growth. These mRNAs harbour a region termed DSR (determinant of selective removal), which is recognized by the YTH family RNA-binding protein Mmi1p. Mmi1p directs the destruction of these mRNAs in collaboration with nuclear exosomes. However, detailed molecular mechanisms underlying this...
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