Article
The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.
The Journal of biological chemistry - 18 Jan 2008
Katsoulotos Gregory P, Qi Miao, Qi Jian Cheng, Tanaka Kumiko, Hughes William E, Molloy Timothy J, Adachi Roberto, Stevens Richard L, Krilis Steven A
Abstract excerpt
Ras guanine nucleotide-releasing protein 4 (RasGRP4) is a mast cell (MC)-restricted guanine nucleotide exchange factor and diacylglycerol (DAG)/phorbol ester receptor. An RasGRP4-defective variant of the human MC line HMC-1 was used to create stable clones expressing green fluorescent protein-labeled RasGRP4 for monitoring the movement of this protein inside MCs after exposure to phorbol 12-myristate 13-acetate...
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