Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of a catalytically inactive form of diacylglycerol kinase alpha induces sustained signaling through RasGRP.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2002

Jones David R, Sanjuán Miguel Angel, Stone James C, Mérida Isabel

Abstract excerpt

Regulating the generation and clearance of lipid second messengers, such as diacylglycerol (DAG), is critical for the correct propagation of intracellular signaling pathways. DAGK type alpha acts as a negative modulator of the DAG levels generated during T cell activation, which is initiated by triggering of the endogenous T cell receptor (TCR), as well as by stimulation of an ectopically expressed human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbachol
Share to Catalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diacylglycerol Kinase

Share to Guanine Nucleotide Exchange Factors

Share to Indicators and Reagents

Share to Luminescent Proteins

Share to Mitogen-Activated Protein Kinases

Share to Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 11919165
DOI: 10.1096/fj.01-0762fje

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of a catalytically inactive form of diacylglycerol kinase alpha induces sustained signaling through RasGRP.PMID 11919165Read ↗

Diacylglycerol kinase gamma serves as an upstream suppressor of Rac1 and lamellipodium formation.Semantic proximity Read ↗

Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.Semantic proximity Read ↗

The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.Semantic proximity Read ↗

Membrane interactions of G proteins and other related proteins.Semantic proximity Read ↗

Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.Semantic proximity Read ↗

Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin.Semantic proximity Read ↗

Characterization of constitutively active mutants of G protein-coupled receptors.Semantic proximity Read ↗

Phospholipase Cdelta1 is a guanine nucleotide exchanging factor for transglutaminase II (Galpha h) and promotes alpha 1B-adrenoreceptor-mediated GTP binding and intracellular calcium release.Semantic proximity Read ↗

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1.Semantic proximity Read ↗

Activator of G-protein signaling 1 blocks GIRK channel activation by a G-protein-coupled receptor: apparent disruption of receptor signaling complexes.Semantic proximity Read ↗

Overexpression of wild-type and catalytically inactive forms of GRK2 and GRK6 fails to alter the agonist-induced phosphorylation of the C5a receptor (CD88): evidence that GRK6 is autophosphorylated in COS-7 cells.Semantic proximity Read ↗

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.