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Article

Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.

The Biochemical journal - 1 Sept 2007

Johnson Joanne E, Goulding Rebecca E, Ding Ziwei, Partovi Amir, Anthony Kira V, Beaulieu Nadine, Tazmini Ghazaleh, Cornell Rosemary B, Kay Robert J

Abstract excerpt

RasGRPs (guanine-nucleotide-releasing proteins) are exchange factors for membrane-bound GTPases. All RasGRP family members contain C1 domains which, in other proteins, bind DAG (diacylglycerol) and thus mediate the proximal signal-transduction events induced by this lipid second messenger. The presence of C1 domains suggests that all RasGRPs could be regulated by membrane translocation driven by C1-DAG...

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Identifiers

PMID: 17523924
DOI: 10.1042/BJ20070294
PMCID: PMC1948961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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