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Article

Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor

2 Mar 2011

Abstract excerpt

C3G (Crk SH3-domain-binding guanine-nucleotide-releasing factor) is a ubiquitously expressed member of a class of molecules called GEFs (guanine-nucleotide-exchange factor) that activate small GTPases and is involved in pathways triggered by a variety of signals. It is essential for mammalian embryonic development and many cellular functions in adult tissues. C3G participates in regulating functions that require...

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PMID: 21366540
DOI: 10.1042/bsr20100094

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