Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.

doi:10.1016/j.bbamem.2017.09.010

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Article

Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.

Biochimica et biophysica acta. Biomembranes - 1 Dec 2017

Czikora Agnes, Kedei Noemi, Kalish Heather, Blumberg Peter M

Abstract excerpt

RasGRP comprises a family of guanine nucleotide exchange factors, regulating the dissociation of GDP from Ras GTPases to enhance the formation of the active GTP-bound form. RasGRP1 possesses REM (Ras exchange), GEF (catalytic), EF-hand, C1, SuPT (suppressor of PT), and PT (plasma membrane-targeting) domains, among which the C1 domain drives membrane localization in response to diacylglycerol or phorbol ester and...

Topics

Amino Acid Sequence
Binding Sites
Cell Line, Tumor
Cell Membrane
Cloning, Molecular
DNA-Binding Proteins
Diglycerides
Epithelial Cells
Escherichia coli
Gene Expression
Green Fluorescent Proteins
Guanine Nucleotide Exchange Factors
Humans

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Models, Molecular

Mutation

Protein Binding

Protein Interaction Domains and Motifs

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Identifiers

PMID: 28912101
DOI: 10.1016/j.bbamem.2017.09.010
PMCID: PMC5659902

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