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Article

Molecular pathogenesis of mantle cell lymphoma

1 Oct 2012

Abstract excerpt

Mantle cell lymphoma is a B cell malignancy in which constitutive dysregulation of cyclin D1 and the cell cycle, disruption of DNA damage response pathways, and activation of cell survival mechanisms contribute to oncogenesis. A small number of tumors lack cyclin D1 overexpression, suggesting that its dysregulation is always not required for tumor initiation. Some cases have hypermutated IGHV and stable...

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PMID: 23023712
DOI: 10.1172/jci61272

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