Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The molecular pathogenesis of mantle cell lymphoma.

Leukemia & lymphoma - 1 Jul 2017

Vogt Niklas, Dai Beiying, Erdmann Tabea, Berdel Wolfgang E, Lenz Georg

Abstract excerpt

Mantle cell lymphoma (MCL) is characterized by the translocation t(11;14) leading to constitutive cyclin D1 overexpression. However, overexpression of cyclin D1 alone is insufficient to cause malignant transformation. Secondary genetic alterations and deregulated signaling pathways involved in DNA damage response, cell proliferation, and apoptosis are indispensable for MCL lymphomagenesis. Recent studies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Cyclin D1
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genetic Variation

Share to Lymphoma, Mantle-Cell

Share to Molecular Targeted Therapy

Share to Signal Transduction

Source

Identifiers

PMID: 27894215
DOI: 10.1080/10428194.2016.1248965

Genes

BCL2
BCR
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The molecular pathogenesis of mantle cell lymphoma.PMID 27894215Read ↗

Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic eraSemantic proximity Read ↗

Molecular pathogenesis of mantle cell lymphomaSemantic proximity Read ↗

Pathogenesis of Mantle-Cell Lymphoma: All Oncogenic Roads Lead to Dysregulation of Cell Cycle and DNA Damage Response PathwaysSemantic proximity Read ↗

Mantle cell lymphoma: report of the 2010 Mantle Cell Lymphoma Consortium WorkshopSemantic proximity Read ↗

NOTCH Signaling in Mantle Cell Lymphoma: Biological and Clinical Implications.Semantic proximity Read ↗

Mantle Cell Lymphoma Under the Scope of Personalized Medicine: Perspective and Directions.Semantic proximity Read ↗

Mantle cell lymphoma: biology, clinical presentation, and therapeutic approaches.Semantic proximity Read ↗

Biological and clinical determinants shaping heterogeneity in mantle cell lymphomaSemantic proximity Read ↗

Mantle cell lymphoma: evolving management strategies.Semantic proximity Read ↗

Novel agents for mantle cell lymphoma: molecular rational and clinical data.Semantic proximity Read ↗

Unraveling MCL biology to understand resistance and identify vulnerabilitiesSemantic proximity Read ↗

Molecular Pathogenesis of Mantle Cell Lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.