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Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis

6 Apr 2012

Abstract excerpt

miRNA deregulation has been implicated in the pathogenesis of mantle cell lymphoma (MCL). Using a high-throughput quantitative real-time PCR platform, we performed miRNA profiling on cyclin D1-positive MCL (n = 30) and cyclin D1-negative MCL (n = 7) and compared them with small lymphocytic leukemia/lymphoma (n = 12), aggressive B-cell lymphomas (n = 138), normal B-cell subsets, and stromal cells. We identified a...

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PMID: 22490335
DOI: 10.1182/blood-2011-07-370122

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