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Article

HDM4 is overexpressed in mantle cell lymphoma and its inhibition induces p21 expression and apoptosis.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2010

Liang Mei, Han Xin, Vadhan-Raj Saroj, Nguyen Martin, Zhang Yu H, Fernandez Michael, Drakos Elias, Konoplev Sergej N, Yin C Cameron, Miranda Roberto N, McDonnell Timothy J, Medeiros L Jeffrey, Bueso-Ramos Carlos E

Abstract excerpt

In mouse models and cell lines, murine double minute 2 (MDM2) and MDM4 have been shown to synergistically promote proteasome-mediated degradation of p21 and p53. MDM4 also inhibits p53-mediated transcriptional activation of p21. p53 expression results in increased p21 expression, a negative cell-...

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Share to Cyclin-Dependent Kinase Inhibitor p21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymph Nodes

Share to Lymphoma, Follicular

Share to Lymphoma, Large B-Cell, Diffuse

Share to Lymphoma, Mantle-Cell

Share to RNA Interference

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Source

Identifiers

PMID: 20062013
DOI: 10.1038/modpathol.2009.170

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20062013-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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