Behind the scenes of non-nodal MCL: downmodulation of genes involved in actin cytoskeleton organization, cell projection, cell adhesion, tumour invasion, TP53 pathway and mutated status of immunoglobulin heavy chain genes.

doi:10.1111/j.1365-2141.2011.08962.x

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Article

Behind the scenes of non-nodal MCL: downmodulation of genes involved in actin cytoskeleton organization, cell projection, cell adhesion, tumour invasion, TP53 pathway and mutated status of immunoglobulin heavy chain genes.

British journal of haematology - 1 Mar 2012

Del Giudice Ilaria, Messina Monica, Chiaretti Sabina, Santangelo Simona, Tavolaro Simona, De Propris Maria Stefania, Nanni Mauro, Pescarmona Edoardo, Mancini Francesca, Pulsoni Alessandro, Martelli Maurizio, Di Rocco Alice, Finolezzi Erica, Paoloni Francesca, Mauro Francesca R, Cuneo Antonio, Guarini Anna, Foà Robin

Abstract excerpt

Mantle cell lymphoma (MCL) is an aggressive neoplasm with a short survival. Cases with leukaemic MCL and splenomegaly without adenopathies (non-nodal MCL) may have a more indolent course. To gain insights into the biological features underlying this presentation, we investigated the gene expression profile (GEP) and the IGHV mutational status in a cohort of leukaemic MCL cases. Comparison of MCL with other...

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Identifiers

PMID: 22150124
DOI: 10.1111/j.1365-2141.2011.08962.x

Genes

CELSR1
ETS1
EZR
ITGAE
OCIAD1
PCDH9
PGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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