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Article

Targeting of AID-mediated sequence diversification to immunoglobulin genes.

Current opinion in immunology - 1 Apr 2011

Kothapalli Naga Rama, Fugmann Sebastian D

Abstract excerpt

Activation-induced cytidine deaminase (AID) is a key enzyme for antibody-mediated immune responses. Antibodies are encoded by the immunoglobulin genes and AID acts as a transcription-dependent DNA mutator on these genes to improve antibody affinity and effector functions. An emerging theme in field is that many transcribed genes are potential targets of AID, presenting an obvious danger to genomic integrity. Thus...

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Identifiers

PMID: 21295456
DOI: 10.1016/j.coi.2010.12.009
PMCID: PMC3073656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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