Article
PIK3CA cancer mutations display gender and tissue specificity patterns.
Human mutation - 1 Feb 2008
Benvenuti Silvia, Frattini Milo, Arena Sabrina, Zanon Carlo, Cappelletti Vera, Coradini Danila, Daidone Maria Grazia, Pilotti Silvana, Pierotti Marco A, Bardelli Alberto
Abstract excerpt
The occurrence of oncogenic alleles can display striking tissue specificity. For example KRAS mutations are very frequent in pancreatic cancers but relatively rare in melanomas. The opposite is true for BRAF mutations. Somatic mutations in the gene encoding for the phosphatidylinositol 3-kinase (PI3KCA) catalytic subunit, PIK3CA, occur at high frequency in many solid cancers. We have examined whether PI3K...
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