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Article

The protein degradation response of Saccharomyces cerevisiae to classical DNA-damaging agents.

Chemical research in toxicology - 1 Dec 2007

Burgis Nicholas E, Samson Leona D

Abstract excerpt

Genome wide experiments indicate both proteasome- and vacuole-mediated protein degradation modulate sensitivity to classical DNA-damaging agents. Here, we show that global protein degradation is significantly increased upon methyl methanesulfonate (MMS) exposure. In addition, global protein degradation is similarly increased upon exposure to 4-nitroquinoline-N-oxide (4NQO) and UV and, to a lesser extent,...

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Identifiers

PMID: 18020423
DOI: 10.1021/tx700126e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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