Article
Using DNA damage sensitivity phenotypes to characterize mutations affecting proteasome function.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012
Tallec Benoît Le, Peyroche Anne
Abstract excerpt
Most mutants affected either in the proteasome biogenesis or function accumulate polyubiquitylated proteins and display growth defects at 37°C or in the presence of canavanine, an arginine analog that impairs protein synthesis. We uncovered a new striking phenotype related to DNA damage for some proteasome mutants: mutant strains grew better than the wild type in the presence of specific genotoxic agents (4NQO,...
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