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Article

Yeast Rpn4 Links the Proteasome and DNA Repair via RAD52 Regulation.

International journal of molecular sciences - 30 Oct 2020

Spasskaya Daria S, Nadolinskaia Nonna I, Tutyaeva Vera V, Lysov Yuriy P, Karpov Vadim L, Karpov Dmitry S

Abstract excerpt

Environmental and intracellular factors often damage DNA, but multiple DNA repair pathways maintain genome integrity. In yeast, the 26S proteasome and its transcriptional regulator and substrate Rpn4 are involved in DNA damage resistance. Paradoxically, while proteasome dysfunction may induce hyper-resistance to DNA-damaging agents, Rpn4 malfunction sensitizes yeasts to these agents. Previously, we proposed that...

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Source

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Identifiers

PMID: 33143019
DOI: 10.3390/ijms21218097
PMCID: PMC7672625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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