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Article

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer

15 Nov 2007

Abstract excerpt

BACKGROUND: Transforming growth factor beta (TGFbeta) is important in colorectal cancer (CRC) progression. Bone morphogenetic proteins (BMPs), a subgroup within the TGFbeta superfamily, recently also have been implicated in CRC, but their precise role in CRC has yet to be investigated. METHODS: The authors used a tissue microarray and immunohistochemistry of BMP receptors and signal transduction elements in...

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PMID: 18008360
DOI: 10.1002/cncr.23160

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