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Article

Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer.

The Journal of pathology - 1 Jun 2017

Irshad Shazia, Bansal Mukesh, Guarnieri Paolo, Davis Hayley, Al Haj Zen Ayman, Baran Brygida, Pinna Claudia Maria Assunta, Rahman Haseeb, Biswas Sujata, Bardella Chiara, Jeffery Rosemary, Wang Lai Mun, East James Edward, Tomlinson Ian, Lewis Annabelle, Leedham Simon John

Abstract excerpt

The functional role of bone morphogenetic protein (BMP) signalling in colorectal cancer (CRC) is poorly defined, with contradictory results in cancer cell line models reflecting the inherent difficulties of assessing a signalling pathway that is context-dependent and subject to genetic constraints. By assessing the transcriptional response of a diploid human colonic epithelial cell line to BMP ligand stimulation,...

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Identifiers

PMID: 28299802
DOI: 10.1002/path.4891
PMCID: PMC5488238

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